ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ Π±ΠΈΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ² N-ΠΊΠΎΠ½ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ° ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠ° Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Π-ΡΠΈΠΏΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
Π£ΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½Π° BNP ΠΈ ΡΠ΅ΠΊΡΠ΅ΡΠΈΡ BNP ΠΈ NT-proBNP Π² ΠΊΡΠΎΠ²ΠΎΡΠΎΠΊ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ (Π‘Π). Π‘Π΅ΡΠ΄Π΅ΡΠ½Π°Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ ΡΠ΅ΡΠ΄ΡΠ΅ Π½Π΅ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·Ρ ΠΌ ΠΊΡΠΎΠ²ΡΡ Π² Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π°Ρ , ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π² Π²ΠΈΠ΄Π΅ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΡ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² (ΠΎΠ΄ΡΡΠΊΠ°, ΡΡΠΎΠΌΠ»ΡΠ΅ΠΌΠΎΡΡΡ, ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΠΎΡΠ΅ΠΊΠΈ, Π²Π»Π°ΠΆΠ½ΡΠ΅ Ρ ΡΠΈΠΏΡ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- 1. 1. ΠΠ°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄Ρ
- 1. 1. 1. Π‘Π΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 1. 1. 2. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 1. 2. Π‘ΠΈΠ½ΡΠ΅Π· ΠΈ ceKpeijim BNP
- 1. 2. 1. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ BNP Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠΊΠ°Π½ΡΡ
- 1. 2. 2. Π‘ΡΡΡΠΊΡΡΡΠ° Π³Π΅Π½Π° BNP
- 1. 2. 3. Π Π΅Π³ΡΠ»ΡΡΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½Π° BNP
- 1. 2. 4. ΠΡΠΎΡΠ΅ΡΡΠΈΠ½Π³ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠ° BNP
- 1. 2. 5. Π€ΠΎΡΠΌΡ BNP Π² ΠΊΡΠΎΠ²ΠΈ
- 1. 2. 6. ΠΠΎΠ½Π²Π΅ΡΡΠ°Π·Ρ ΠΏΡΠΎΠ³ΠΎΡΠΌΠΎΠ½ΠΎΠ², ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡΠΈΠ΅ ΡΡΠ°ΡΡΠΈΠ΅ Π² ΠΏΡΠΎΡΠ΅ΡΡΠΈΠ½Π³Π΅ proBNP
- 1. 2. 7. ΠΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ½ΡΠ³Π΅ ΡΠΎΡΠΌΡ proBNP ΠΈ NT-proBNP
- 1. 3. ΠΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 1. 4. Π Π΅ΡΠ΅ΠΏΡΠΎΡΡ Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 1. 5. Π€ΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ BNP
- 1. 6. Π‘Π΅ΡΠ΄Π΅ΡΠ½Π°Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡ
- 1. 6. 1. ΠΠ±Π³ΡΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°
- 1. 6. 2. ΠΠ΅ΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅ ΠΏΡΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ
- 1. 6. 3. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ BNP ΠΈ NT-proBNP Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅
- 1. 7. ΠΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ NT-proBNP Π² ΠΊΡΠΎΠ²ΠΈ
- 1. 1. ΠΠ°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄Ρ
- 2. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 2. 1. 1. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΡΠΠ’-23Π° (+)-NT-proBNP Π΄Π»Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ NT-proBNP Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π. col
- 2. 1. 2. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ NT-proBNP. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π»ΠΈΠ·Π°ΡΠ° ΠΊΠ»Π΅ΡΠΎΠΊ Π. col
- 2. 1. 3. ΠΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ² Ρ Π±Π΅Π»ΠΊΠΎΠΌ-Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ
- 2. 1. 4. ΠΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΡ ΠΌΡΡΠ΅ΠΉ ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π»ΠΈΠ½ΠΈΠΉ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π»Π°, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΠ΅ ΠΊ NT-proBNP
- 2. 1. 5. ΠΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΠΉ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΡΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·Ρ
- 2. 1. 6. ΠΠ‘Π-ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π² ΠΏΠΎΠ»ΠΈΠ°ΠΊΡΡΠ°ΠΌΠΈΠ΄Π½ΠΎΠΌ Π³Π΅Π»Π΅
- 2. 1. 7. ΠΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π² ΡΡΠΈΡ-ΡΡΡΠΈΠΈΠΎΠ²ΠΎΠΉ Π±ΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅
- 2. 1. 8. ΠΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ², ΠΈΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ Π½Π° Π½ΠΈΡΡΠΎΡΠ΅Π»Π»ΡΠ»ΠΎΠ·Π½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅
- 2. 1. 9. ΠΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Π½Π° BrCN-Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΡΠΎΠ·Π΅
- 2. 1. 10. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ NT-proBNP ΠΈΠ· ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π°ΡΡΠΈΠ½Π½ΠΎΠΉ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ
- 2. 1. 11. Π€Π΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ NT-proBNP
- 2. 1. 12. Π₯ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ²
- 2. 1. 13. Π’ΡΠΈΠΏΡΠΈΠ½ΠΎΠ»ΠΈΠ· ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ NT-proBNP ΠΈ Π΄Π΅Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ΄Π° Π°ΠΌΠΌΠΎΠ½ΠΈΡ
- 2. 1. 14. ΠΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ·
- 3. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅
- 3. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΎΡΠΈΡΡΠΊΠ°ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ NT-proBNP
- 3. 1. 1. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈpET-23a (+)-NT-proBNP Π΄Π»Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ NT-proBNP Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π. col
- 3. 1. 2. ΠΡΠΈΡΡΠΊΠ° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ NT-proBNP
- 3. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π», ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ
ΠΊ NT-proBNP
- 3. 2. 1. ΠΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ² Ρ Π±Π΅Π»ΠΊΠΎΠΌ- Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΡ ΠΌΡΡΠ΅ΠΉ
- 3. 2. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π»ΠΈΠ½ΠΈΠΉ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π»Π°, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΠ΅ ΠΊ NT- proBNP
- 3. 2. 3. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΏΠΈΡΠΎΠΏΠ½ΠΎΠΉ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π»
- 3. 3. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ NT-proBNP
- 3. 3. 1. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ NT-proBNP, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΌΡΡ Π² ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ Π‘Π
- 3. 3. 2. ΠΡΠΎΡΠ΅ΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄Π΅Π³ΡΠ°Π΄Π°ΡΠΈΡ NT-proBNP ΠΈ Π΅Π΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ Ρ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡΠΈ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ
- 3. 3. 3. ΠΡΠΎΠ²Π΅ΡΠΊΠ° Π³ΠΈΠΏΠΎΡΠ΅Π·Ρ ΠΎ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠΈ NT-proBNP Π² ΠΊΡΠΎΠ²ΠΈ Π² Π²ΠΈΠ΄Π΅ Π³ΠΎΠΌΠΎ- ΠΈΠ»ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ²
- 3. 3. 4. ΠΠ»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ NT-proBNP ΠΈ Π΅Π³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ
- 3. 3. 5. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ°ΠΉΡΠΎΠ² Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ NT-proBNP ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ MALDI-MS/MS
- 3. 4. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π-Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ NT-proBNP, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ· ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΡ ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΏΠ»Π°Π·ΠΌΡ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ Π‘Π
- 3. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΎΡΠΈΡΡΠΊΠ°ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ NT-proBNP
- ΠΡΠ²ΠΎΠ΄Ρ
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- Altschul, S. F., Madden, Π’. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W. &1.pman, D. J. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389−402.
- Arden, Π. C., Viars, C. S., Weiss, S., Argentin, S. & Nemer, M. 1995. Localization ofthe human B-type natriuretic peptide precursor (NPPB) gene to chromosome lp36. Genomics 26: 385−9.
- Bettencourt, P., Ferreira, A., Dias, P., Castro, A., Martins, L. & Cerqueira-Gomes, M.2000. Evaluation of brain natriuretic peptide in the diagnosis of heart failure.1. Cardiology 93: 19−25.
- Brandt, I., Lambeir, A. M., Ketelslegers, J. M., Vanderheyden, M., Scharpe, S. & De
- Meester, I. 2006. Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form. Clin Chem 52: 82−7.
- Campbell, D. J., Mitchelhill, Π. I., Schlicht, S. M. & Booth, R. J. 2000. Plasma aminoterminal pro-brain natriuretic peptide: a novel approach to the diagnosis of cardiac dysfunction. J Card Fail 6: 130−9.
- Chan, J. C., Knudson, O., Wu, F., Morser, J., Dole, W. P. & Wu, Q. 2005. Hypertensionin mice lacking the proatrial natriuretic peptide convertase corin. Proc Natl Acad Sci USA 102: 785−90.
- Cheng, V., Kazanagra, R., Garcia, A., Lenert, L., Krishnaswamy, P., Gardetto, N.,
- Clopton, P. & Maisel, A. 2001. A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 37: 386−91.
- Chinkers, M. & Garbers, D. L. 1989. The protein kinase domain of the ANP receptor is required for signaling. Science 245: 1392−4.
- Cortes, R., Rivera, M., Salvador, A., Garcia de Burgos, F., Bertomeu, V., Rosello-Lleti,
- E., Martinez-Dolz, L., Paya, R., Almenar, L. & Portoles, M. 2007. Urinary B-type natriuretic peptide levels in the diagnosis and prognosis of heart failure. J Card Fail 13: 549−55.
- Crimmins, D. L. & Kao, J. L. 2008. A glycosylated form of the human cardiac hormonepro B-type natriuretic peptide is an intrinsically unstructured monomeric protein. Arch Biochem Biophys 475: 36−41.
- Davidson, N. C., Naas, A. A., Hanson, J. K., Kennedy, N. S., Coutie, W. J. & Struthers,
- A. D. 1996. Comparison of atrial natriuretic peptide B-type natriuretic peptide, and N-terminal proatrial natriuretic peptide as indicators of left ventricular systolic dysfunction. Am J Cardiol 77: 828−31.
- Del Ry, S., Passino, C., Emdin, M. & Giannessi, D. 2006. C-type natriuretic peptide andheart failure. Pharmacol Res 54: 326−33.
- Dubois, Π‘. M., Laprise, M. H., Blanchette, F., Gentry, L. E. & Leduc, R. 1995.
- Processing of transforming growth factor beta 1 precursor by human furin convertase. J Biol Chem 270: 10 618−24.
- Emdin, M., Passino, C., Prontera, C., Fontana, M., Poletti, R., Gabutti, A., Mammini, C.,
- Giannoni, A., Zyw, L., Zucchelli, G. & Clerico, A. 2007. Comparison of brain natriuretic peptide (BNP) and amino-terminal ProBNP for early diagnosis of heart failure. Clin Chem 53: 1289−97.
- Fenrick, R., Babinski, K., McNicoll, N., Therrien, M., Drouin, J. & De Lean, A. 1994.
- Cloning and functional expression of the bovine natriuretic peptide receptor-B (natriuretic factor Rlc subtype. Mol Cell Biochem 137: 173−82.
- Flynn, T. G., de Bold, M. L. & de Bold, A. J. 1983. The amino acid sequence of an atrialpeptide with potent diuretic and natriuretic properties. Biochem Biophys Res Commun 117: 859−65.
- Fuat, A., Murphy, J. J., Hungin, A. P., Curry, J., Mehrzad, A. A., Hetherington, A.,
- Johnston, J. I., Smellie, W. S., Duffy, V. & Cawley, P. 2006. The diagnostic accuracy and utility of a B-type natriuretic peptide test in a community population of patients with suspected heart failure. Br J Gen Pract 56: 327−33.
- Gerbes, A. L., Dagnino, L., Nguyen, T. & Nemer, M. 1994. Transcription of brainnatriuretic peptide and atrial natriuretic peptide genes in human tissues. J Clin Endocrinol Metab 78:1307−11.
- Giuliani, I., Rieunier, F., Larue, C., Delagneau, J. F., Granier, Π‘., Pau, Π., Ferriere, M.,
- Saussine, M., Cristol, J. P., Dupuy, A. M., Merigeon, E., Merle, D. & Villard, S. 2006. Assay for measurement of intact B-type natriuretic peptide prohormone in blood. Clin Chem 52: 1054−61.
- Gladysheva, I. P., Robinson, B. R., Houng, A. K., Kovats, T. & King, S. M. 2008. Corinis co-expressed with pro-ANP and localized on the cardiomyocyte surface in both zymogen and catalytically active forms. JMol Cell Cardiol 44: 131−42.
- Goetze, J. P., Dahlstrom, U., Rehfeld, J. F. & Alehagen, U. 2008. Impact of Epitope
- Specificity and Precursor Maturation in Pro-B-Type Natriuretic Peptide Measurement. Clin Chem.
- Goetze. J. P., Jensen, G., Moller, S., Bendtsen, F., Rehfeld, J. F. & Henriksen, J. H.2006. BNP and N-terminal proBNP are both extracted in the normal kidney. Eur J Clin Invest 36: 8−15.
- Goodfriend, T. L., Elliott, M. E. & Atlas, S. A. 1984. Actions of synthetic atrialnatriuretic factor on bovine adrenal glomerulosa. Life Sci 35: 1675−82.
- Gustafsson, F., Steensgaard-Hansen, F., Badskjaer, J., Poulsen. A. H., Corell. P. &
- Hildebrandt, P. 2005. Diagnostic and prognostic performance of N-terminal ProBNP in primary care patients with suspected heart failure. J Card Fail 11: SI 5−20.
- Hammerer-Lercher, A., Fersterer, J., Holzmann, S., Bonatti, J., Ruttmann, E., Hoefer, D.,
- Mair, J. & Puschendorf, B. 2006. Direct comparison of relaxation and cGMP production in human coronary by-pass grafts in response to stimulation with natriuretic peptides and a nitric oxide donor. Clin Sci (bond) 111: 225−31.
- Hammerer-Lercher, A., Neubauer, E., Muller, S., Pachinger, O., Puschendorf, B. & Mair,
- J. 2001. Head-to-head comparison of N-terminal pro-brain natriuretic peptide, brain natriuretic peptide and N-terminal pro-atrial natriuretic peptide in diagnosing left ventricular dysfunction. Clin ChimActa 310: 193−7.
- Hanford, D. S., Thuerauf, D. J., Murray, S. F. & Glembotski, Π‘. C. 1994. Brainnatriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes. J Biol Chem 269: 26 227−33.
- Harris, P. J., Thomas, D. & Morgan, Π’. O. 1987. Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption. Nature 326: 697−8.
- Hashiguchi, Π’., Higuchi, K., Ohashi, M., Minamino, N., Kangawa, K., Matsuo, H. &
- Nawata, H. 1988. Porcine brain natriuretic peptide, another modulator of bovine adrenocortical steroidogenesis. FEBSLett 236: 455−61.
- He, X. 1., Chow, D. c., Martick, M. M. & Garcia, Π. C. 2001. Allosteric activation of aspring-loaded natriuretic peptide receptor dimer by hormone. Science 293: 165 762.
- Hermanson, G. 1996. Bioconjugate techniques. Academic press Inc.
- Heublein, D. M., Huntley, Π. K., Boerrigter, G" Cataliotti, A., Sandberg, S. M., Redfield,
- M. M. & Burnett, J. C. Jr 2007. Immunoreactivity and guanosine 3', 5'-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide. Hypertension 49: 1114−9.
- Hino, J., Tateyama, H., Minamino, N., Kangawa, K. & Matsuo, H. 1990. Isolation andidentification of human brain natriuretic peptides in cardiac atrium. Biochem Biophys Res Commun 167: 693−700.
- Hirata, Y., Shichiri, M., Emori, Π’., Marumo, F., Kangawa, K. & Matsuo, H. 1988. Brainnatriuretic peptide interacts with atrial natriuretic peptide receptor in cultured rat vascular smooth muscle cells. FEBS Lett 238: 415−8.
- Hughes, D., Talwar, S., Squire, I. Π., Davies, J. E. & Ng, L. L. 1999. Animmunoluminometric assay for N-terminal pro-brain natriuretic peptide: development of a test for left ventricular dysfunction. Clin Sci (Lond) 96: 373−80.
- Hunt, P. J., Espiner, E. A., Nicholls, M. G., Richards, A. M. & Yandle, T. G. 1996.
- Differing biological effects of equimolar atrial and brain natriuretic peptide infusions in normal man. J Clin Endocrinol Me tab 81: 3871−6.
- Hunt, P. J., Espiner, E. A., Nicholls, M. G., Richards, A. M. & Yandle, T. G. 1997a. Therole of the circulation in processing pro-brain natriuretic peptide (proBNP) to amino-terminal BNP and BNP-32. Peptides 18: 1475−81.
- Hunt, P. J., Richards, A. M., Nicholls, M. G., Yandle, T. G., Doughty, R. N. & Espiner,
- E. A. 1997b. Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment. Clin Endocrinol (Oxf) 47: 28 796.
- Hunt, P. J. Yandle, T. G., Nicholls, M. G., Richards, A. M. & Espiner, E. A. 1995. Theamino-terminal portion of pro-brain natriuretic peptide (Pro-BNP) circulates in human plasma. Biochem Biophys Res Commun 214: 1175−83.
- Itoh, H., Nakao, K., Mukoyama, M., Saito, Y., Yamada, Π’., Shirakami, G., Arai, H.,
- Hosoda, K., Suga, S., Yoshida, I. & et, a. 1. 1990. Preparation of monoclonal antibodies against brain natriuretic peptide and their application to radioimmunoassay and passive immunization. Endocrinology 127: 1292−300.
- Januzzi, J. L., van Kimmenade, R., Lainchbury, J., Bayes-Genis, A., Ordonez-Llanos, J.,
- Januzzi, J. L. Jr, Camargo, C. A., Anwaruddin, S., Baggish, A. L., Chen, A. A., Krauser,
- Jensen, Π. Π’., Carstens, J. & Pedersen, E. B. 1998. Effect of BNP on renalhemodynamics, tubular function and vasoactive hormones in humans. Am J Physiol 21 A: F63−72.
- Jewett, J. R., Koller, K. J., Goeddel, D. V. & Lowe, D. G. 1993. Hormonal induction oflow affinity receptor guanylyl cyclase. EMBOJX 2: 769−77.
- Jourdain, P., Jondeau, G., Funck, F., Gueffet, P., Le Helloco, A., Donal, E., Aupetit, J. F.,
- Aumont, M. C., Galinier, M., Eicher, J. C., Cohen-Solal, A. & Juilliere, Y. 2007. Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure: the STARS-BNP Multicenter Study. J Am Coll Cardiol 49: 1733−9.
- Julenius, Π., Molgaard, A., Gupta, R. & Brunak, S. 2005. Prediction, conservationanalysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology 15: 153−64.
- Karl, J., Borgya, A., Gallusser, A., Huber, E., Krueger, K., Rollinger, W. & Schenk, J.1999. Development of a novel, N-terminal-proBNP (NT-proBNP) assay with a low detection limit. Scand J Clin Lab Invest Suppl 230: 177−81.
- Kearney, M. T. & Marber, M. 2004. Trends in incidence and prognosis of heart failure-
- You always pass failure on the way to success. Eur Heart J25: 283−4.
- Kilic, A., Bubikat, A., Gassner, Π., Baba, H. A. & Kuhn, M. 2007. Local actions of atrialnatriuretic peptide counteract angiotensin II stimulated cardiac remodeling. Endocrinology 148: 4162−9.
- Kimura, K., Yamaguchi, Y., Horii, M., Kawata, H., Yamamoto, H" Uemura, S. & Saito,
- Y. 2007. ANP is cleared much faster than BNP in patients with congestive heart failure. Eur J Clin Pharmacol 63: 699−702.
- Kishimoto, I., Dubois, S. K. & Garbers, D. L. 1996. The heart communicates with thekidney exclusively through the guanylyl cyclase-A receptor: acute handling of sodium and water in response to volume expansion. Proc Natl Acad Sci US A 93: 6215−9.
- Knappe, S. Wu, F., Masikat, M. R., Morser, J. & Wu, Q. 2003. Functional analysis ofthe transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. J Biol Chem 278: 52 363−70.
- Kohler, G. & Milstein, C. 1975. Continuous cultures of fused cells secreting antibody ofpredefined specificity. Nature 256: 495−7.
- Kudo, T. & Baird, A. 1984−1985. Inhibition of aldosterone production in the adrenalglomerulosa by atrial natriuretic factor. Nature 312: 756−7.
- Kuhn, M. 2003. Structure, regulation, and function of mammalian membrane guanylylcyclase receptors, with a focus on guanylyl cyclase-A. Circ Res 93: 700−9.
- Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head ofbacteriophage T4. Nature 227: 680−5.
- Lam, Π‘. S., Burnett, J. C. Jr, Costello-Boerrigter, L., Rodeheffer, R. J. & Redfield, M. M.2007. Alternate circulating pro-B-type natriuretic peptide and B-type natriuretic peptide forms in the general population. J Am Coll Cardiol 49: 1193−202.
- Lang, Π‘. C., Prasad, N., McAlpine, H. M., Macleod, C., Lipworth, B. J., MacDonald, T.
- M. & Struthers, A. D. 1994. Increased plasma levels of brain natriuretic peptide in patients with isolated diastolic dysfunction. Am HeartJXTJ: 1635−6.
- LaPointe, M. C. 2005. Molecular regulation of the brain natriuretic peptide gene.1. Peptides 26: 944−56.
- Latini, R., Masson, S., Anand, I., Salio, M., Hester, A., Judd, D., Barlera, S., Maggioni,
- A. P., Tognoni, G. & Cohn, J. N. 2004. The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT. Eur Heart J 25: 292−9.
- Light, D. Π., Corbin, J. D. & Stanton, B. A. 1990. Dual ion-channel regulation by cyclic
- GMP and cyclic GMP-dependent protein kinase. Nature 344: 336−9.
- Lopez, M. J., Garbers, D. L. & Kuhn, M. 1997. The guanylyl cyclase-deficient mousedefines differential pathways of natriuretic peptide signaling. J Biol Chem 272: 23 064−8.
- Lowe, D. G. 1992. Human natriuretic peptide receptor-A guanylyl cyclase is selfassociated prior to hormone binding. Biochemistry 31: 10 421−5.
- Lowe, D. G., Camerato, T. R. & Goeddel, D. V. 1990. cDNA sequence of the humanatrial natriuretic peptide clearance receptor. Nucleic Acids Res 18: 3412.
- Lowe, D. G., Chang, M. S., Hellmiss, R., Chen, E., Singh, S., Garbers, D. L. & Goeddel,
- D. V. 1989. Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction. EMBOJ 8: 1377−84.
- Maack, Π’., Marion, D. N., Camargo, M. J., Kleinert, H. D., Laragh, J. H., Vaughan, E. D.
- Jr & Atlas, S. A. 1984. Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs. Am J Med 77: 1069−75.
- Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Due, P.,
- Marin-Grez, M., Fleming, J. T. & Steinhausen, M. 1986. Atrial natriuretic peptide causespre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney. Nature 324: 473−6.
- Marttila, M., Hautala, N., Paradis, P., Toth, M., Vuolteenaho, O., Nemer, M. &
- Ruskoaho, H. 2001. GATA4 mediates activation of the B-type natriuretic peptide gene expression in response to hemodynamic stress. Endocrinology 142: 4 693 700.
- Masson, S., Latini, R" Anand, I. S., Vago, Π’., Angelici, L., Barlera, S., Missov, E. D.,
- Michielsen, E. C., Bakker, J. A., Kimmenade, R. R., Pinto, Y. M. & Dieijen-Visser, M. P.2008. The diagnostic value of serum and urinary NT-proBNP for heart failure. Ann Clin Biochem 45: 389−94.
- Minamino, N., Aburaya, M., Ueda, S., Kangawa, K. & Matsuo, H. 1988. The presenceof brain natriuretic peptide of 12,000 daltons in porcine heart. Biochem Biophys Res Commun 155: 740−6.
- Miyagi, M. & Misono, K. S. 2000. Disulfide bond structure of the atrial natriureticpeptide receptor extracellular domain: conserved disulfide bonds among guanylate cyclase-coupled receptors. Biochim Biophys Acta 1478: 30−8.
- Miyagi, M., Zhang, X. & Misono, Π. S. 2000. Glycosylation sites in the atrial natriuretic peptide receptor: oligosaccharide structures are not required for hormone binding. Eur JBiochem 267: 5758−68.
- Molloy, S. S., Bresnahan, P. A., Leppla, S. H., Klimpel, K. R. & Thomas, G. 1992.
- Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem 267: 16 396−402.
- Mosterd, A. & Hoes, A. W. 2007. Clinical epidemiology of heart failure. Heart 93:1137−46.
- Mueller, Π’., Gegenhuber, A., Poelz, W. & Haltmayer, M. 2003. Comparison of the
- Biomedica NT-proBNP enzyme immunoassay and the Roche NT-proBNP chemiluminescence immunoassay: implications for the prediction of symptomatic and asymptomatic structural heart disease. Clin Chem 49: 976−9.
- Mueller, Π’., Gegenhuber, A., Poelz, W. & Haltmayer, M. 2005. Diagnostic accuracy of
- Π type natriuretic peptide and amino terminal proBNP in the emergency diagnosis of heart failure. Heart 91: 606−12.
- Mukoyama, M., Nakao, K., Hosoda, K., Suga, S., Saito, Y., Ogawa, Y., Shirakami, G.,
- Nakagawa, O., Ogawa, Y., Itoh, H., Suga, S., Komatsu, Y., Kishimoto, I., Nishino, K.,
- Nussenzveig, D. R., Lewicki, J. A. & Maack, T. 1990. Cellular mechanisms of theclearance function of type Π‘ receptors of atrial natriuretic factor. J Biol Chem 265: 20 952−8.
- Ogawa, Y., Itoh, H., Tamura, N., Suga, S., Yoshimasa, Π’., Uehira, M., Matsuda, S.,
- Shiono, S., Nishimoto, H. & Nakao, K. 1994. Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene. J Clin Invest 93: 1911−21.
- Ogawa, Y., Nakao, K., Mukoyama, M., Hosoda, K., Shirakami, G., Arai, H., Saito, Y.,
- Suga, S., Jougasaki, M. & Imura, H. 1991. Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide. Π‘ ire Res 69: 491−500.
- Ogawa, Y., Tamura, N.- Chusho, H. & Nakao, K. 2001. Brain natriuretic peptide appearsto act locally as an antifibrotic factor in the heart. Con J Physiol Pharmacol 79: 723−9.
- Okumura, K. Yasue, H., Fujii, H., Kugiyama, K., Matsuyama, K., Yoshimura, M.,
- Oliver, P. M., Fox, J. E., Kim, R., Rockman, H. Π., ΠΠ»Ρ, H. S., Reddick, R. L., Pandey,
- K. N., Milgram, S. L., Smithies, O. & Maeda, N. 1997. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci USA 94: 14 730−5.
- Omland, Π’., Persson, A., Ng, L., O’Brien, R., Karlsson, Π’., Herlitz, J., Hartford, M. &
- Caidahl, K. 2002. N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes. Circulation 106: 2913−8.
- Ozaki, J., Shimizu, H., Hashimoto, Y., Itoh, H., Nakao, K. & Inui, K. 1999. Enzymaticinactivation of major circulating forms of atrial and brain natriuretic peptides. Eur J Pharmacol 370: 307−12.
- Pankow, K., Wang, Y., Gembardt, F., Krause, E., Sun, X., Krause, G., Schultheiss, H. P.,
- Siems, W. E. & Walther, T. 2007. Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res 101: 875−82.
- Pemberton, Π‘. J., Johnson, M. L., Yandle, T. G. & Espiner, E. A. 2000. Deconvolution analysis of cardiac natriuretic peptides during acute volume overload. Hypertension 36: 355−9.
- Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. Π’., Aitken, G. D. &
- Espiner, E. A. 1997. Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. J Endocrinol 155: 541−50.
- Pidgeon, G. Π., Richards, A. M., Nicholls, M. G., Espiner, E. A., Yandle, T. G. &
- Frampton, C. 1996. Differing metabolism and bioactivity of atrial and brain natriuretic peptides in essential hypertension. Hypertension 27: 906−13.
- Pikkarainen, S., Tokola, H., Majalahti-Palviainen, Π’., Kerkela, R., Hautala, N. Bhalla, S.
- S., Charron, F., Nemer, M., Vuolteenaho, O. & Ruskoaho, H. 2003. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. J Biol Chem 278: 23 807−16.
- Porter, J. G., Arfsten, A., Palisi, Π’., Scarborough, R. M., Lewicki, J. A. & Seilhamer, J. J.1989. Cloning of a cDNA encoding porcine brain natriuretic peptide. J Biol Chem 264: 6689−92.
- Potter, L. R., Abbey-Hosch, S. & Dickey, D. M. 2006. Natriuretic peptides, theirreceptors, and cyclic guanosine monophosphate-dependent signaling functions. EndocrRev 27: 47−72.
- Potter, L. R. & Hunter, T. 2001. Guanylyl cyclase-linked natriuretic peptide receptors: structure and regulation. J Biol Chem 276: 6057−60.
- Rademaker, G. J. Pergantis, S. A., Blok-Tip, L. Langridge, J. I., Kleen, A. & Thomas
- Oates, J. E. 1998. Mass spectrometric determination of the sites of O-glycan attachment with low picomolar sensitivity. Anal Biochem 257: 149−60.
- Rademaker, M. Π’., Charles, C. J., Kosoglou, Π’., Protter, A. A., Espiner, E. A., Nicholls,
- M. G. & Richards, A. M. 1997. Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. Am J Physiol 273: H2372−9.
- Rosenkranz, A. C., Woods, R. L., Dusting, G. J. & Ritchie, R. H. 2003. Antihypertrophicactions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP. Cardiovasc Res 57: 515−22.
- Rutten, J. H., Boomsma, F. & van den Meiracker, A. H. 2006. Higher renal extraction of
- ANP compared with NT-proANP, BNP and NT-proBNP. Eur J Clin Invest 36: 514−5.
- Sawada, Y., Inoue, M., Kanda, Π’., Sakamaki, Π’., Tanaka, S., Minamino, N., Nagai, R. &
- Takeuchi, T. 1997. Co-elevation of brain natriuretic peptide and proprotein-processing endoprotease furin after myocardial infarction in rats. FEBS Lett 400: 177−82.
- Scarborough, R. M., Schenk, D. Π., McEnroe, G. A., Arfsten, A. Kang, L. L., Schwartz,
- K. & Lewicki, J. A. 1986. Truncated atrial natriuretic peptide analogs. Comparison between receptor binding and stimulation of cyclic GMP accumulation in cultured vascular smooth muscle cells. J Biol Chem 261: 129 604.
- Schagger, H. & von Jagow, G. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gelelectrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal BiochetJ2 166: 368−79.
- Schellenberger, U., O’Rear, J., Guzzetta, A., Jue, R. A., Protter, A. A. & Pollitt, N. S.2006. The precursor to B-type natriuretic peptide is an O-linked glycoprotein. Arch Biochem Biophys 451: 160−6.
- Schiller, P. W., Maziak, L., Nguyen, Π’. M., Godin, J., Garcia, R., De Lean, A. & Cantin,
- M. 1985. Synthesis and biological activity of a linear fragment of the atrial natriuretic factor (ANF). Biochem Biophys Res Commiin 131: 1056−62.
- Schirger, J. A., Heublein, D. M., Chen, H. H., Lisy, O., Jougasaki, M., Wennberg, P. W.
- Burnett, J. C. Jr 1999. Presence of Dendroaspis natriuretic peptide-like immunoreactivity in human plasma and its increase during human heart failure. Mayo Clin Proc 74: 126−30.
- Schoenfeld, J. R., Sehl, P., Quan, C., Burnier, J. P. & Lowe, D. G. 1995. Agonistselectivity for three species of natriuretic peptide receptor-A. Mol Pharmacol 47: 172−80.
- Schoenfeld, J. R., Tom, J. Y. & Lowe, D. G. 1997. Mutations in B-type natriuretic peptide mediating receptor-A selectivity. FEBS Lett 414: 263−7.
- Seferian, K. R., Tamm, N. N., Semenov, A. G., Mukharyamova, K. S., Tolstaya, A. A.,
- Seidler, Π’., Pemberton, C., Yandle, Π’., Espiner, E., Nicholls, G. & Richards, M. 1999.
- The amino terminal regions of proBNP and proANP oligomerise through leucine zipper-like coiled-coil motifs. Biochem Biophys Res Commun 255: 495−501.
- Seilhamer, J. J., Arfsten, A., Miller, J. A., Lundquist, P., Scarborough, R. M., Lewicki, J.
- A. & Porter, J. G. 1989. Human and canine gene homologs of porcine brain natriuretic peptide. Biochem Biophys Res Commun 165: 650−8.
- Semenov, A. G., Postnikov, Π. Π., Tamm, N. N., Seferian, K. R., Karpova, N. S.,
- Bloshchitsyna, M. N., Koshkina, E. V., Krasnoselsky, M. I., Serebryanaya, D. V. & Katrukha, A. G. 2009. Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in the region close to the cleavage site. Clin Chem 55: 489−98.
- Shimekake, Y., Kawabata, Π’., Nakamura, M. & Nagata, K. 1992. The role of the Cterminal region of rat brain natriuretic peptide in receptor selectivity. FEBS Lett 309: 185−9.
- Shimizu, H., Masuta, Π., Aono, K., Asada, H., Sasakura, K., Tamaki, M., Sugita, K. &
- Yamada, K. 2002. Molecular forms of human brain natriuretic peptide in plasma. Clin Chim Acta 316: 129−35.
- Shimizu, H., Masuta, K., Asada, H., Sugita, K. & Sairenji, T. 2003. Characterization ofmolecular forms of probrain natriuretic peptide in human plasma. Clin Chim Acta 334:233−9.
- Song, D. L., Kohse, K. P. & Murad, F. 1988. Brain natriuretic factor. Augmentation ofcellular cyclic GMP, activation of particulate guanylate cyclase and receptor binding. FEBS Lett 232: 125−9.
- Steg, P. G., Joubin, L., McCord, J-, Abraham, W. Π’., Hollander, J. E., Omland, Π’.,
- Mentre, F., McCullough, P. A. & Maisel, A. S. 2005. B-type natriuretic peptide and echocardiography determination of ejection fraction in the diagnosis of congestive heart failure in patients with acute dyspnea. Chest 128: 21−9.
- Stingo, A. J., Clavell, A. L., Heublein, D. M., Wei, Π‘. M., Pittelkow, M. R. & Burnett, J.
- C. Jr 1992. Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Physiol 263: H1318−21.
- Sudoh, Π’., Kangawa, K., Minamino, N. & Matsuo, H. 1988. A new natriuretic peptide inporcine brain. Nature 332: 78−81.
- Sudoh, Π’., Maekawa, K., Kojima, M., Minamino, N., Kangawa, K. & Matsuo, H. 1989.
- Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide. Biochem Biophys Res Commun 159: 1427−34.
- Sudoh, Π’., Minamino, N., Kangawa, K. & Matsuo, H. 1990. C-type natriuretic peptide
- CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 168: 863−70.
- Suga, S., Nakao, K., Hosoda, K., Mukoyama, M., Ogawa, Y., Shirakami, G., Arai, H.,
- Saito, Y., Kambayashi, Y., Inouye, K. & et, a. 1. 1992. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130: 229−39.
- Takahashi, N., Saito, Y., Kuwahara, K., Harada, M., Kishimoto, I., Ogawa, Y.,
- Talwar, S., Squire, I. Π., Davies, J. E., Barnett, D. B. & Ng, L. L. 1999. Plasma Nterminal pro-brain natriuretic peptide and the ECG in the assessment of left-ventricular systolic dysfunction in a high risk population. Eur Heart J 20: 173 644.
- Tamura, N., Ogawa, Y., Chusho, H., Nakamura, K., Nakao, K., Suda, M., Kasahara, M.,
- Hashimoto, R., Katsuura, G., Mukoyama, M., Itoh, H., Saito, Y., Tanaka, I., Otani, H. & Katsuki, M. 2000. Cardiac fibrosis in mice lacking brain natriureticpeptide. Proc Natl Acad Sci USA 97: 4239−44.
- Tateyama, H., Hino, J., Minamino, N., Kangawa, K., Minamino, Π’., Sakai, K., Ogihara,
- T. & Matsuo, H. 1992. Concentrations and molecular forms of human brain natriuretic peptide in plasma. Biochem Biophys Res Commun 185: 760−7.
- Thuerauf, D. J. & Glembotski, Π‘. C. 1997. Differential effects of protein kinase C, Ras, and Raf-1 kinase on the induction of the cardiac B-type natriuretic peptide gene through a critical promoter-proximal M-CAT element. J Biol Chem 272: 7464−72.
- Thuerauf, D. J., Hanford, D. S. & Glembotski, Π‘. C. 1994. Regulation of rat brainnatriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. J Biol Chem 269: 17 772−5.
- Togashi, K., Fujita, S. & Kawakami, M. 1992. Presence of brain natriuretic peptide inurine. Clin Chem 38: 322−3.
- Togashi, K., Hirata, Y., Ando, K., Takei, Y., Kawakami, M. & Marumo, F. 1989. Brainnatriuretic peptide-like immunoreactivity is present in human plasma. FEBS Lett 250: 235−7.
- Troughton, R. W., Frampton, Π‘. M., Yandle, T. G., Espiner, E. A., Nicholls, M. G. &
- Richards, A. M. 2000. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet 355: 1126−30.
- Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor. Nature 406: 101−4.
- Vanneste, Y., Pauwels, S., Lambotte, L. & Deschodt-Lanckman, M. 1990. In vivometabolism of brain natriuretic peptide in the rat involves endopeptidase 24.11 and angiotensin converting enzyme. Biochem Biophys Res Π‘ΠΎΡΡΠΈΠΏ 1Πͺ: 265−71.
- Varki, A., Cummings, RD., Esko, JD., Freez, HH., Hart, GW. & Etzler, ME. 2008.
- Essentials of glycobiology. NY: Cold Spring Harbor Laboratory Press.
- Vogt-Schaden, M., Gagelmann, M., Hock, D., Herbst, F. & Forssmann, W. G. 1989.
- Degradation of porcine brain natriuretic peptide (pBNP-26) by endoprotease-24.11 from kidney cortical membranes. Biochem Biophys Res Commun 161: 1177−83.
- Watanabe, Π’. X., Noda, Y., Chino, N., Nishiuchi, Y., Kimura, Π’., Sakakibara, S. & Imai,
- M. 1988. Structure-activity relationships of alpha-human atrial natriuretic peptide. Eur J Pharmacol 147: 49−57.
- Watanabe, Y., Nakajima, K., Shimamori, Y. & Fujimoto, Y. 1997. Comparison of thehydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11. Biochem Mol Med 61: 47−51.
- Wilson, E. M. & Π‘hinkers, M. 1995. Identification of sequences mediating guanylylcyclase dimerization. Biochemistry 34: 4696−701.
- Wright, S. P., Doughty, R. N., Pearl, A., Gamble, G. D., Whalley, G. A., Walsh, H. J.,
- Gordon, G., Bagg, W., Oxenham, H., Yandle, Π’., Richards, M. & Sharpe, N. 2003. Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: a randomized, controlled trial. J Am Coll Cardiol 42: 1793−800.
- Wu, C., Wu, F., Pan, J., Morser, J. & Wu, Q. 2003. Furin-mediated processing of Pro-Ctype natriuretic peptide. J Biol Chem 278:25 847−52.
- Yamamoto, K., Burnett, J. C. Jr, Jougasaki, M., Nishimura, R. A., Bailey, K. R., Saito,
- Y., Nakao, K. & Redfield, M. M. 1996. Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension 28: 988−94.
- Yan, W., Sheng, N., Seto, M., Morser, J. & Wu, Q. 1999. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. J1. Biol Chem 274: 14 926−35.
- Yan, W., Wu, F., Morser, J. & Wu, Q. 2000. Corin, a transmembrane cardiac serineprotease, acts as a pro-atrial natriuretic peptide-converting enzyme. Proc Natl AcadSci USA 97: 8525−9.
- Yandle, Π’., Fisher, S., Espiner, E., Richards, M. & Nicholls, G. 1999. Validatingaminoterminal BNP assays: a word of caution. Lancet 353: 1068−9.
- Yasue. H., Yoshimura, M., Sumida, H., Kikuta, K., Kugiyama, K., Jougasaki, M.,
- ΠΠΈΠ½ΠΎΠ³ΡΠ°Π΄ΠΎΠ², Π.Π. ΠΈ Π―ΠΌΡΠΊΠΎΠ², ΠΠ. 1998. ΠΠ΅Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π»ΠΈΠΊΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠ².
- ΠΠΈΠΎΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ ΠΈΠΌΠΈΡ. 24: 803−815.
- ΠΡΡΠ΅ΡΠΌΠ°Π½ JI.A. 1985. Π₯ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΈ Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΡ ΠΊΠΈΡΠ»ΠΎΡ. ΠΠΎΡΠΊΠ²Π°: ΠΠ°ΡΠΊΠ°.