Естественная цитотоксическая активность дендритных клеток против клеток опухолевых линий и активированных лимфоцитов
Дендритные клетки (ДК), будучи профессиональными антигенпрезентирующими клетками, играют ведущую роль в запуске специфического противоопухолевого и противовирусного иммунного ответа. Благодаря высокой плотности антигенпредставляющих молекул МНС I и II классов, экспрессии костимуляторных молекул (СБ80, СЭ86) и продукции широкого спектра цитокинов и хемокинов ДК обладают способностью активировать… Читать ещё >
Содержание
- Список сокращений
ГЛАВА 1. ДЕНДРИТНЫЕ КЛЕТКИ. РОЛЬ ЦИТОТОКСИЧЕСКОЙ АКТИВНОСТИ ДЕНДРИТНЫХ КЛЕТОК В ИММУННОМ ОТВЕТЕ (Обзор литературы).
1.1. ХАРАКТЕРИСТИКА ДЕНДРИТНЫХ КЛЕТОК.
1.1.1. Общие сведения о дендритных клетках.:.
1.1.2. Фенотипические и функциональные особенности различных типов дендритных клеток.
1.2. ЦИТОТОКСИЧЕСКАЯ АКТИВНОСТЬ ДЕНДРИТНЫХ КЛЕТОК
1.2.1. Молекулярные механизмы, опосредующие гибель клеток-мишеней
1.2.2. Цитотоксическая активность ДК против опухолевых клеток.
1.2.3. Цитотоксическая активность ДК против иммуннокомпетентных клеток.
1.3. СРАВНИТЕЛЬНАЯ ХАРАКТЕРИСТИКА №N01- И 11−4-ИНДУЦИРОВАННЫХ ДЕНДРИТНЫХ КЛЕТОК.
ГЛАВА 2. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ.
2.1. ХАРАКТЕРИСТИКА БОЛЬНЫХ, ВКЛЮЧЕННЫХ В ИССЛЕДОВАНИЕ.
2.2. ИММУНОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ.
2.2.1. Получение дендритных клеток и супернатантов цельных культур
2.2.2. Определение субпопуляций клеток методом проточной цитофлуориметрии.
2.2.3. Определение цитотоксической активности ИФН-ДК.
2.2.4.0ценка аллостимуляторной активности ИФН-ДК.
2.2.5. Определение продукции цитокинов методом иммуноферментного анализа.
2.3.СТАТИСТИЧЕСКАЯ ОБРАБОТКА ПОЛУЧЕННЫХ РЕЗУЛЬТАТОВ
ГЛАВА 3. РЕЗУЛЬТАТЫ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ.
3.1. ПРОТИВООПУХОЛЕВАЯ ЦИТОТОКСИЧЕСКАЯ АКТИВНОСТЬ ИФН-ДК IN VITRO.
3.2. ЦИТОТОКСИЧЕСКАЯ АКТИВНОСТЬ ИФН-ДК БОЛЬНЫХ ОПУХОЛЯМИ ГОЛОВНОГО МОЗГА.
3.3. РЕГУЛЯЦИЯ ЦИТОТОКСИЧЕСКОЙ АКТИВНОСТИ ИФН-ДК IN VITRO.
3.3.1. Коррекция цитотоксической активности ИФН-ДК при онкопатологии.
3.3.2. Гормональная регуляция цитотоксической активности ИФН-ДК in vitro.
3.4. ЦИТОТОКСИЧЕСКАЯ АКТИВНОСТЬ ИФН-ДК ПРОТИВ 1 ЛИМФОЦИТОВ И NK-КЛЕТОК.
ОБСУЖДЕНИЕ.
Список литературы
- Блиндарь В.Н., Зубрихина Г. Н., Круглова Н. Б., Никитина Т. А. Определение поглотительной способности нейтрофилов и моноцитов периферической крови // Клиническая лабораторная диагностика. 1996. — № 2.-С. 18−20.
- Козлов В.К., Молчанов O.E., Жаринов Г. М. Иммунотерапия рекомбинантными цитокинами в лечении онкологических больных // Успехи клинической иммунологии и аллергологии. 2002. — Т. III.- С. 263−279.
- Леплина О.Ю., Тихонова М.А, Козлов Ю. П., Ступак В. В., Останин A.A., Черных Е. Р. Характеристика IFNa-индуцированных дендритных клеток у больных злокачественными глиомами головного мозга // Бюллетень СО РАМН. 2007. — Т. 124, № 2. — С. 27−33.
- Леплина О.Ю., Тихонова М. А., Сахно Л. В., Тыринова Т. В., Останин A.A., Черных Е. Р. Эффект дегидроэпиандростерона сульфата на созревание и функциональные свойства ИНФ-а-индуцированных дендритных клеток // БЭБиМ. 2009. — Т. 147, № 7. — С. 80 — 85.
- Леплина, О.Ю., Ступак В. В., Козлов Ю. П. и др. IFNa-индуцированные дендритные клетки в лечении больных злокачественными глиомами головного мозга // Клеточные технологии в биологии и медицине. 2007. — Т. 2. — С. 92−98.
- Пинегин Б.В. Полиоксидоний новое поколение иммуномодуляторов с известной структурой и механизмом действия // Аллергия, астма и клиническая иммунология. — 2000. — № 1. — С. 27−28.
- Пинегин Б.В., Некрасов A.B., Хаитов P.M. Иммуномодулятор полиоксидоний: механизмы действия и аспекты клинического применения // Цитокины и воспаление. 2004. — № 3. — С. 41−47.
- Прокопович С.К., Винницкий В. Б. Дендритные клетки и перспективы их использования в иммунотерапии злокачественных новообразований // Онкология. 2001. — № 2−3. — С. 126−131.
- Селедцова Н.В., Хонина Н. А., Дударева А. В. и др. Нарушение иммунорегуляторных механизмов у беременных с гиперандрогенией // Бюллетень СО РАМН. 2006. — Т. 1, № 119. — С. 35−40.
- Adema G.J. Dendritic cells from bench to bedside and back // Immunol. Lett. -2009. Vol. 122, № 2. — P. 128−130.
- H.Alexandra N., Cathelin D., Larmonier N., et al. Dendritic cells trigger tumor cell death by a nitric oxide-dependent mechanism // The Journal of Immunology. -2007.-Vol. 179, № 2.-P. 812−818.
- Algeciras-Schimnich A., Griffith T.S., Lynch D.H., Paya C.V. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis // J. Immunol. 1999. — Vol. 162. — P. 5205−5211.
- Almand В., Clark J.I., Nikitina E., et al. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer // J. Immunol. 2001. — Vol. 166. — P. 678−89.
- Akira S., Ishii K.J. Innate immune recognition of, and regulation by, DNA // Trends Immunol. 2006. — Vol. 27, № 11. — P. 525−32.
- Alyamkina E.A., Dolgova E.V., Likhacheva A.S., et al. Combined therapy with cyclophosphamide and DNA preparation inhibits the tumor growth in mice // Genet. Vaccines Ther. 2009. — Vol. 7. — P. 12.
- An X.J., Bai C.X., Xia J.B., et al. Immature dendritic cells expressing Indoleamine 2,3-Dioxygenase suppress ovalbumin-induced allergic airway inflammation in mice // J. Investig. Allergol. Clin. Immunol. 2011. — Vol. 21, № 3. -P. 185−192.
- Arpinati M., Green C.L., Heimfeld S., et al. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells // Blood. 2000. — Vol. 95. -P.2484−2490.
- Austyn J.M. Dendritic cells // Curr. Opin. Hematol. 1998. — Vol. 5, № 1. — P. 3−15.
- Baetu T.M., Kwon H., Sharma S., et al. Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression // J Immunol. 2001. — Vol. 167, № 6. — P. 3164−3173.
- Baggiolini M. Chemokines and leukocyte traffic // Nature. 1998. — Vol. 392. -P. 565−568.
- Banchereau J., Steinman R.M. Dendritic cells and the control of immunity // Nature. 1998. — Vol. 392. — P. 245−252.
- Barry M., Bleackley R.C. Cytotoxic T lymphocytes: all roads lead to death // Nat. Rev. Immunol. 2002. — Vol. 2. — P. 401−409.
- Bazzoni F., Beutler B. The tumor necrosis factor ligand and receptor families // Engl. J. Med. 1996. — Vol.334. — P. 1717−1725.
- Becker Y. Dendritic cell activity against primary tumors: an overview // In Vivo. 1993. — Vol. 7. — P. 187−191.
- Beignon A.S., McKenna K., Skoberne M., et al. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions // J. Clin. Invest. 2005. — Vol. 115, № 11. — P. 3265−3275.
- Benjamim C.F., Lundy S.K., Lukacs N.W., Hogaboam C.M., Kunkel S.L. Reversal of long-term sepsis-induced immunosuppression by dendritic cells // Blood. 2005. — Vol. 105. — P. 3588−3595.
- Benson Jr. D.M., Bakan C.E., Mishra A., et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody // Blood. 2010. — Vol. 116, № 13.-P. 2286−2294.
- Bigotti G., Coli A., Castagnola G. Distribution of Langerhans cells and HLA class II molecules in prostatic carcinomas of different histopathological grade // Prostate. 1991. — Vol. 19. — P.73−87.
- Blanco P., Palucka A.K., Gill M., Pascual V., Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus // Science. 2001. — Vol. 294. — P. 1540−1543.
- Bodmer J.L., Holler N., Reynard S., et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8 // Nat. Cell Biol. 2000. — Vol. 2. — P. 241−243.
- Bogdan C. The function of type I interferons in antimicrobial immunity // Curr. Opin. Immunol. 2000. — Vol. 12. — P. 419−424.
- Bosque A., Pardo J., Martinez-Lorenzo M.J., et al. Human CD8+T cell blasts are more sensitive than CD4+T cell blasts to regulation by AP02L/TRAIL // Eur. J. Immunol. 2005. — Vol. 35. — P. 1812−1821.
- Bouman A., Heineman M.J., Faas M.M. Sex hormones and the immune response in humans // Human Reproduction Update. 2005. — Vol. 11, № 4. — P. 411—423.
- Butts C.L., Bowers E., Horn J.C., et al. Inhibitory Effects of Progesterone Differ in Dendritic Cells from Female and Male Rodents // Gend Med. 2008. -Vol. 5, № 4. — P. 434−447.
- Barber G. N. STING-dependent signaling // Nature Immunology. 2011. -Vol.12.-P.929−930.
- Caron G., Delneste Y., Aubry J.-P., et al. Human NK cells constitutively express membrane TNF-a (mTNFa) and present mTNFa-dependent cytotoxic activity // Eur. J. of Immunology. 1999. — Vol. 29, № 1. — P. 3588−3595.
- Caron G., Delneste Y., Roelandts E., Duez C., Bonnefoy J.Y., Pestel J., Jeannin P. Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells // J. Immunol. 2001. — Vol. 167. — P.3682−3686.
- Caux C., Liu Y.J., Banchereau J. Recent advances in the study of dendritic cells and follicular dendritic cells // Immunol Today. 1995. — Vol. 16, № 1. — P. 2−4.
- Cella M., Jarrossay D., Facchetti F., et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon // Nat. Med. 1999.-Vol. 5. -P. 919−923.
- Chaperot L., Blum A., Manches O., et al. Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells // J. Immunol. -2006. Vol. 176. — P. 248−255.
- Chauvin C., Josien R. Dendritic cells as killers: mechanistic aspects and potential roles // J. Immunol. 2008. — Vol. 18. — P. 11−16.
- Chavez-Galan L., Arenas-Del Angel M.C., Zenteno E., et al. Cell death mechanisms induced by cytotoxic lymphocytes // Cell Mol. Immunol. 2009. -Vol. 6, № 1. — P. 15−25.
- Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity // Nat. Rev. Immunol. 2004. — Vol. 4. — P. 336−347.
- Chen L., Zhang Zh., Chen W., et al. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B // The J. of Immunology. 2007. — Vol. 178, № 10. — P. 6634−6641.
- Chen M.L., Pittet M.J., Gorelik L., et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo // Proc. Natl. Acad. Sci. U. S. A. 2005. — Vol. 102. — P. 419−424.
- Chiao P.J., Miyamoto S., Verma I.M. Autoregulation of IkBa activity // Biochemistry. 1994. — Vol. 91. — P.28−32.
- Coban C., Koyama S., Takeshita F., Akira S., Ishii K.J. Molecular and cellular mechanisms of DNA vaccines // Hum. Vaccin. 2008. — Vol.4. — P.453−456.
- Cohen G.M. Caspases: the executioners of apoptosis // Biochem. J. 1997. -Vol. 326.-P. 1−16.
- Colonna M., Trinchieri G., Liu Y.-J. Plasmacytoid dendritic cells in immunity // Nature Immunol. 2004. — Vol. 5. — P. 1219- 1226.
- Corsini E., Racchi M., Sinforiani E., et al. Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone // J. Leukoc. Biol. 2005. — Vol. 77, № 2. — P. 247−256.
- Curiel T.J., Cheng P., Mottram P., et al. Dendritic cells subsets differentially regulate angiogenesis in human ovarian cancer // Cancer Res. 2004. — Vol. 64. -P. 5535−5538.
- Delia Bella S., Gennaro M., Vaccari M., et al. Altered maturation of peripheral blood dendritic cells in patients with breast cancer// Br. J. Cancer. 2003. — Vol. 89. — P. 1463−1472.
- Della Bella S., Nicola S., Riva A., et al. Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferon-a // Journal of Leukocyte Biology. 2004. — Vol. 75. — P. 106−116.
- Demeure C.E., Wu C.Y., Shu U., et al In vitro maturation of human neonatal CD4T lymphocytes, II: cytokines present at priming modulate the development of lymphokine production // J. Immunol. 1994. — Vol. 152. — P. 4775−4782.
- Di Santo E., Foddi M.C., Ricciardi-Castagnoli P., Mennini T., Ghezzi P. DHEAS inhibits TNF production in monocytes, astrocytes and microglial cells // Neuroimmunomodulation. 1996. — Vol. 3, № 5. — P. 285−288.
- Dong-Ming K., Zhao Q., Xu J., et al. Tumor-Educated Tolerogenic Dendritic Cells Induce CD3s Down-Regulation and Apoptosis of T Cells through Oxygen-Dependent Pathways // The J. of immunology. 2008. — Vol. 181, № 5. — P. 30 893 098.
- Drexler H.G., Quentmeier H. FLT3: Receptor and ligand // Growth Factors.-2004. Vol. 22, № 2. — P. 71−73.
- Ehtesham M.P., Kabos M.A., Gutierrez K., et al. Intratumoral dendritic cell vaccination elicits potent tumoricidal immunity against malignant glioma in rats // J. Immunother. 2003. — Vol. 26. — P. 107−116.
- Emery J. G., McDonnell P., Burke M.B., et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL // J. Biol. Chem. 1998. — Vol. 273. — P. 14 363−14 367.
- Erickson S. L, de Sauvage F.J., Kikly K., et al. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice // Nature. 1999. — Vol. 372. — P. 560−563.
- Fanger N. A., Maliszewski C.R., Schooley K., Griffith T.S. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) // J. Exp. Med. 1999. — Vol. 190. — P. 1155−1164
- Fernandez N.C., Lozier A., Flament C. Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo // Nature Medicine. 1999. — Vol. 5, № 4. — P. 405−411.
- Fishman M. Cytolytic activities of activated macrophages versus paraformaldehyde-fixed macrophages- soluble versus membrane-associated TNF //Cellular Immunology. 1991. — Vol. 137, № 1. — P. 164−174.
- Fraszczak J., Trad M., Janikashvili N., et al. Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells //The Journal of Immunology. 2010. — Vol. 184, № 4. — P. 1876−1884.
- Furset G., Floisand Y., Sioud M. Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands // Immunology. 2007. — Vol. 123. — P. 263−271.
- Gabrilovich D.I., Chen H.L., Girgis K.R., et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells // Nat. Med. 1996. — Vol. 2. — P. 1096−1103.
- Georgopoulos N.T., Steele L.P., Thomson M.J., et al. A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation // Cell Death Differ. 2006. — Vol. 13. — P. 1789−1801.
- Ghiringhelli F., Menard C., Terme M., et al. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner//J. Exp. Med. 2005. — Vol. 202. — P. 1075−1085.
- Gruss H.J. Molecular, structural and biological characteristics of the tumor necrosis factor ligand superfamily // Int. J. Clin. Lab. Res. 1996. — Vol. 26. — P. 143−159.
- Gupta S., Su H., Bi R., et al. Life and death of lymphocytes: a role in immunesenescence // Immunity & Ageing. 2005. — Vol. 2. -P. 12.
- Hart D.N. Dendritic cells: unique leukocyte population which control the primary immune response // Blood. 1997. — Vol. 90. — P. 3245−3287.
- Heil F., Hemmi H., Hochrein H., et al. Species-specific recognition of single-stranded RNA via toll-like receptor-7 and -8 // Science. 2004. — Vol. 303. — P. 1526−1529.
- Hill K.S., Errington F., Steele L.P., et al. OK432-Activated Human Dendritic Cells Kill Tumor Cells via CD40/CD40 Ligand // The Journal of Immunology. -2008. Vol. 181, № 5. — P. 3108−3115.
- Hill M., Tanguy-Royer S., Royer P., et al. IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells // Eur. J. Immunol. 2007. — Vol. 37. — P. 3054−3062.
- Hoffmann T.K., Muller-Berghaus J., Ferris R.L., et al. Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients withsquamous cell carcinomas of the head and neck// Clin. Cancer Res. 2002. -Vol. 8.-P. 1787−1793.
- Holen I., Croucher P.I., Hamdy F.C., Eaton C.L. Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells // Cancer Res. 2002. — Vol. 62. — P. 1619−1623.
- Horiuchi T., Mitoma H., Harashima S., Tsukamoto H., Shimoda T. Transmembrane TNF-a: structure, function and interaction with anti-TNF agents // Rheumatology. 2010. — Vol. 49, № 7. — P. 1215−1228.
- Hoves S., Krause S., Scholmerich J., Fleck M. The JAM-assay: optimized conditions to determine death-receptor-mediated apoptosis // Methods. 2003. -Vol. 31. — P. 127−134.
- Hoves S., Krause S.W., Herfarth H., et al. Elimination of activated but not resting primary human CD4+ and CD8+T cells by Fas ligand (FasL/CD95L)-expressing killer-dendritic cells // Immunobiology. 2004. — Vol. 208. — P. 463 475.
- Hsu S.C., Gavrilin M.A., Lee H.H., et al. NF-kappa B-dependent Fas ligand expression // Eur. J. Immunol. 1999. — Vol. 29, № 9. — P. 2948−2956.
- Hubert P., Glannini S.L., Vanderplasschen A., et al. Dendritic cells induce the death of human papillomavirus-transformed keratinocytes // FASEB J. 2001. — P. 2521−2523.
- Janjic B.M., Lu G., Pimenov A., et al. Innate direct anticancer effector function of human immature dendritic cells. I. Involvement of an apoptosis-inducing pathway // J. Immunol. 2002. — Vol. 168. — P. 1823−1830.
- Jego G., Palucka A.K., Blanck J.P., Chalouni C., Pascual V., Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6 // Immunity. 2003. — Vol. 19. — P. 225−234.
- Jeremias I., Herr I., Boehler T., Debatin K.M. TRAIL/Apo-2-ligand-induced apoptosis in human T cells // Eur. J. Immunol. 1998. — Vol. 28, № 1. — P. 143−152.
- Jiang M., Liu Z., Xiang Y, et al. Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma // BMC Cancer. 2011. — Vol. 11.- P.54.
- Jones L. A, Kreem S., Shweash M., Paul A., et al. Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone // J. Immunol. 2010. — Vol. 185, № 8. — P. 4525−4534.
- Joo H.-G., Fleming T.P., Tanaka Y., et al. Human dendritic cells induce tumor-specific apoptosis by soluble factors // Int. J. Cancer 2002. — Vol. 102. — P. 20 -28.
- Kadowaki N., Antonenko S., Lau J.Y., Liu Y.J. Natural interferon a/|3-producing cells link innate and adaptive immunity // J. Exp. Med. 2000. — Vol. 192.-P. 219−226.
- Kalinski P., Hilkens C.M., Wierenga E.A., Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal // Immunol. Today. 1999. — Vol. 20. — P. 561−567.
- Kapsenberg M.L. Hilkens C.M., van Der Pouw Kraan T.C., Wierenga E.A., Kalinski P. Atopic allergy: a failure of antigen-presenting cells to properly polarize helper T cells? // Am. J. Respir. Crit. Care Med. 2000. — Vol. 162. — P. 76−80.
- Katz S.I., Tamaki K. Epidermal Langerhans cells are derived from cells originating in bone marrow // Nature. 1979. — Vol. 282, № 5736. — P. 324−326.
- Kayagaki N., Yamaguchi N., Nakayama M., et al. Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells // The Journal of Immunology. 1999. — Vol. 163, № 4. — P. 1906−1913.
- Kawai T., Kumar H., Akira S. Pathogen recognition by the innate immune system // Int. Rev. Immunol. 2011. — Vol. 30, № 1. — P. 16−34.
- King C., Davies J., Mueller R., et al. TGF-fil alters APC preference, polarizing islet antigen responses toward a Th2 phenotype // Immunity. 1998. -Vol. 8.-P. 601−613.
- Knight M., Riffkin C., Muscat A., Ashley D., Hawkins C. Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells // Oncogene.- 2001.-Vol. 20.-P. 5789−5798.
- Kohrgruber N., Halanek N., Groger M., et al. Survival, maturation, and function of CD 11c" and CDllc+ peripheral blood dendritic cells are differentially regulated by cytokines // J. Immunol. 1999. — Vol. 163. — P. 3250−3259.
- Korthals M., Safaian N., Kronenwett R. et al. Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysis // J. Transl. Med. 2007. — Vol. 25. — P. 46−48.
- Kuchroo V.K., Das M.P., Brown J.A., et al. B7−1 and B7−2 costimulatory molecules activate differentially the Thl/Th2 developmental pathways: application to autoimmune disease therapy // Cell 1995. — Vol. 80. — P. 707−718.
- Kuwana M., Kaburaki J., Wright T.M., Kawakami Y., Ikeda Y. Induction of antigen-specific human CD4+T cell anergy by peripheral blood DC2 precursors // Eur. J. Immunol. 2001. — Vol. 31. — P. 2547−2557.
- Lakomy D., Janikashvili N., Fraszczak J., et al. Cytotoxic dendritic cells generated from cancer patients // J. Immunol. 2011. — Vol. 187. — P. 2775−2782.
- Lapenta C., Santini S., Spada ML, et al. IFN-a-conditioned dendritic cells are highly efficient in inducing cross-priming CD8+ T cells against exogenous viral antigens // Eur. J. Immunol. 2006. — Vol. 36. — P. 2046−2060.
- Laskarin G., Strbo N., Sotosek V., et al. Progesterone directly and indirectly affects perforin expression in cytolytic cells // Am. J. Reprod. Immunol. 1999. -Vol. 42, № 5. -P. 312−320.
- Latchman Y.E., Liang S.C., Chernova Y., et al. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells // Proc. Natl. Acad. Sci. USA. 2004. — Vol. 101. — P. 1 069 110 696.
- Le Poole I.C., ElMasri W.M., Denman C.J., et al. Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells // Cancer Immunol. Immunother. 2008. — Vol. 57. — P. 789−797.
- Lee N., Cheong H., Kim S., et al. Ex vivo purging of leukemia cells using tumor-necrosis-factor-related apoptosis-inducing ligand in hematopoietic stem cell transplantation // Leukemia. 2003. — Vol. 17. — P. 1375−1383.
- Legge K.L., Braciale T.J. Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression //Immunity. 2005. — Vol. 23. — P. 649−659.
- Lim J.P., Gleeson P.A. Macropinocytosis: an endocytic pathway for internalising large gulps // Immunology and Cell Biology. 2011. — Vol. 89. — P. 836−843.
- Li P., Nijhawan D., Wang X. Mitochondrial activation of apoptosis // Cell. -2004.-Vol. 116. -P.57−92.
- Lichtner M., Maranon C., Azocar O., et al. HIV Type 1-Infected Dendritic Cells Induce Apoptotic Death in Infected and Uninfected Primary CD4T Lymphocytes // AIDS Research and Human Retroviruses. 2004. — Vol. 20, № 2. -P. 175−182.
- Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal // Nat. Rev. Immunol. 2003. — Vol. 3. — P. 361−370.
- Lissoni P., Vigore L., Ferranti R. et al. Circulating dendritic cells in early and advanced cancer patients: diminished percent in the metastatic disease // J. Biol. Regul. Homeost. Agents. 1999. — Vol. 13. — P. 216−219.
- Liu Sh., Yu Y., Zhang M., et al. The Involvement of TNF-a-Related Apoptosis-Inducing Ligand in the Enhanced Cytotoxicity of IFN-p-Stimulated Human Dendritic Cells to Tumor Cells // J. Immunol. 2001. — Vol. 166, № 9. — P. 5407−5415.
- Lu F., Fang J., Chen Ch.Q. TNF receptor-associated factor-2 binding site is involved in TNFR75-dependent enhancement of TNFR5 5-induced cell death // Cell Research. 2001. — Vol. 11. — P. 217−222.
- Lu G., Janjic B.M., Janjic J., Whiteside T.L., Storkus W.J., Vujanovic N.L. Innate direct anticancer effector function of human immature dendritic cells. II.
- Role of TNF, lymphotoxin-aip2, Fas ligand, and TNF-related apoptosis-inducing ligand//J. Immunol. 2002. — Vol. 168. — P. 1831−1839.
- Luckey U., Maurer M., Schmidt T., et al. T cell killing by tolerogenic dendritic cells protects mice from allergy // J. Clin. Invest. 2011. — Vol. 121, № 10.-P. 3860−3871.
- Luettiq B., Decker T., Lohmann-Matthes M.L. Evidence for the existence of two forms of membrane tumor necrosis factor: an integral protein and a molecule attached to its receptor // J. Immunol. 1989. — Vol. 143. — P. 4034−4038.
- Luft T., Pang K.C., Thomas E., et al. Type I IFNs enhance the terminal differentiation of dendritic cells // J. Immunol. 1998. — Vol. 161. — P. 1947−1953.
- Lukens J.R., Cruise M. W, Lassen M.G., Hahn Y.S. Blockade of PD-1/B7-H1 interaction restores effector CD8+T cell responses in a hepatitis C virus core murine model // J. Immunol. 2008. — Vol. 180. — P. 4875−4884.
- Lynch D.H., Andreasen A., Maraskovsky E., et al. Flt3 ligand induces tumor regression and antitumor immune responses in vivo // Nat. Med. 1997. — Vol. 3. -P. 625−631.
- Macatonia S.E., Hosken N.A., Litton M., et al. Dendritic cells produce IL-12 and direct the development of Thl cells from naive CD4+T cells // J. Immunol. -1995.-Vol. 154.-P. 5071−5079.
- MacDonald K.P. Characterization of human blood dendritic cell subsets // Blood. 2002. — Vol. 100. — P. 4512−4520.
- Manna P. P., Mohanakumar T. Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro // Journal of Leukocyte Biology. 2002. -Vol. 72, № 2.-P. 312−320.
- Matsuda H., Suda T., Hashizume H., et al. Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood ofpatients with asthma // Am. J. Respir. Crit. Care Med. 2002. — Vol. 166, № 8. — P. 1050−1054.
- Matsui T., Connolly J.E., Michnevitz M., et al. CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions // The Journal of Immunology. 2009. — Vol. 182, № 11. — P. 6815−6823.
- Miller L., Hunt J.S. Regulation of TNF-a production in activated mouse macrophages by progesterone. // The Journal of Immunology. 1998. — Vol. 160. -P. 5098−5104.
- Miner K.T., Croft M. Generation, persistence, and modulation of ThO effector cells: role of autocrine IL-4 and IFN-y // J. Immunol. 1998. — Vol. 160. -P. 5280−5287.
- Mirandola P., Ponti C., Gobbi G., et al. Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity // Blood. 2004. — Vol. 104, № 8. -P. 2418−2424.
- Mohty M., Vialle-Castellano A., Nunes J.A., et al. IFN-a skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities // J. Immunol. 2003. — Vol. 171. — P. 3385−3393.
- Morse M.A., Coleman R.E., Akabani G., et al. Migration of human dendritic cells after injection in patients with metastatic malignancies // Cancer Res. 1999. — Vol. 59. — P. 56−58.
- Morton E., Blaho J. Herpes simplex virus blocks Fas-mediated apoptosis independent of viral activation of NF-kappaB in human epithelial HEp-2 cells // J. Interf. Cyt. Res. 2007. — Vol. 27, № 5. — P. 365−376.
- Moseman E.A., Liang X., Dawson A.J., et al. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+regulatory T cells //J. Immunol. 2004. — Vol. 173. — P. 4433−4442.
- Moser M., Murphy K.M. Dendritic cell regulation of Thl-Th2 development //Nat. Immunol. 2000. — Vol. 1. — P. 199−205.
- Munn D.H., Sharma M.D., Lee J.R., et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase // Science. 2002. -Vol. 297.-P. 1867−1870.
- Muroi M., Muroi Y., Ito N., Rice N.R., Suzuki T. Effects of protease inhibitors on LPS-mediated activation of mouse macrophage cell line (J774) // J. Endotoxin Res. 1995. — Vol. 2. — P. 337.
- Nagata S. Apoptosis by death factor // Cell. 1997. — Vol. 88. — P. 355−365.
- Nguyen K.B., Watford W.T., Salomon R., et al. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection // Science. 2002. — Vol. 297. — P. 2063−2066.
- Nguyen T., Russell J. The regulation of FasL expression during activation-induced cell death (AICD) // Immunology. 2001. — Vol. 103, № 4. — P. 42634.
- Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite: in health and disease // Physiological Reviews. 2007. — Vol. 87, № 1. — P. 315124.
- Papewalis C., Jacobs B., Wuttke M. IFN-a skews monocytes into CD56±expressing dendritic cells with potent functional activities in vitro and in vivo // The Journal of Immunology. 2008. — Vol. 180. — P. 1462−1470.
- Paquette R., Hsu N., Kiertscher S., et al. Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytesinto potent antigen-presenting cells // J. Leukoc. Biol. 1998. — Vol. 64. — P. 358 367.
- Phillips J.H., Lanier L.L. Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis // J. Exp. Med. 1987. — Vol. 164. — P. 814−825.
- Pipkin M.E., Lieberman J. Delivering the kiss of death: progress on understanding how perforin works // Curr. Opin. Immunol. 2007. — Vol. 19. — P. 301−308.
- Piqueras B., Connolly J., Freitas H., et al. Upon viral exposure myeloid and plasmacytoid dendritic cells produce three waves of distinct chemokines to recruit immune effectors // Blood. 2006. — Vol. 107, № 7. — P. 2613−2618.
- Poehlmann H., Schefold J.C., Zuckermann-Becker H., et al. Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis // Critical Care. 2009. — Vol. 13. — P. 119.
- Pulendran B., Banchereau J., Burkeholder S., et al. Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo // J. Immunol. 2000. — Vol. 165. — P. 566−572.
- Rabinovich G. A, Gabrilovich D., Sotomayor E.M. Immunosuppressive strategies that are mediated by tumor cells // Annual Review of Immunology.-2007. Vol. 25, № l. — p. 267−296.
- Raftery M.J., Schwab M., Eibert S.M., et al. Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy // Immunity. 2001. — Vol. 15. — P. 997−1009.
- Ratta M., Fagnoni F., Curti A., et al. Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6 // Blood. 2002. — Vol. 100.-P. 230−237.
- Rissoan M.C., Soumelis V., Kadowaki N., et al. Reciprocal control of T helper cell and dendritic cell differentiation // Science. 1999. — Vol. 283. — P. 1183−1186.
- Robinson S.P., Patterson S., English N., et al. Human peripheral blood contains two distinct lineages of dendritic cells // Eur J Immunol. 1999. — Vol. 29. — P. 2769−2778.
- Romani N., Gruner S., Brang D., et al. Proliferating dendritic cell progenitors in human blood // J. Exp. Med. 1994. — Vol. 180. — P. 83−93.
- Roux St., Apetoh L., Chalmin F., et al. CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer // J. Clin. Invest. 2008. — Vol. 118, № 11. — p. 3751−3761.
- Ruden E., Reardon D.A., Coan A.D., et al. Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma // JCO. 2011. -Vol. 29, № 21.-P. 2918−2923.
- Ryncarz R.E., Anasetti C. Expression of CD86 on human marrow CD34+ cells identifies immunocompetent committed precursors of macrophages and dendritic cells // Blood. 1998. — Vol. 91. — P. 3892−3900.
- Sakamoto J., Teramukai S., Watanabe Y., et al. Meta-analysis of adjuvant immunochemotherapy using OK-432 in patients with resected non-small-cell lung cancer // J. Immunother. 2001. — Vol. 24. — P. 250−256.
- Santiago-Schwarz F., Rappa D.A., Laky K., et al. Stem cell factor augments tumor necrosis factor granulocyte-macrophage colony-stimulating factormediated dendritic cells hematopoiesis // Stem Cells. 1995. — Vol. 13. — P. 186 197.
- Santini S., Lapenta C., Logozzi M. et al. Type I Interferon as a powerful adjuvant for monocyte-derived dendritic cells development and activity in vitro and in HU-PBL-SCID mice // J. Exp. Med. 2000. — Vol. 191. — P. 1777−1788.
- Santini S., Pucchini T., Lapenta C., et al. A new type 1 IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells // Stem cells. 2003. — Vol. 21. — P. 357−362.
- Sarina B., Cortelezzi A., Cattaneo C., et al. In vitro effects of IL-12 and IL-2 on NK cells, cytokine release and clonogenic activity in myelodysplastic syndromes (MDS) // Leukemia. 1997. — Vol. 11. — P. 1726−1731.
- Schaefer U., Voloshanenko O., Willen D., Walczak H. TRAIL: a multifunctional cytokine // Front. Biosc. 2007. — Vol. 12. — P. 3813−3824.
- Scimone M.L., Lutzky V.P., Zittermann S.I., et al. Migration of polymorphonuclear leucocytes is influenced by dendritic cells // Immunology 2005.-Vol. 114.-P. 375−385.
- Selenko-Gebauer N., Majdic O., Szekeres A., et al. B7-H1 (Programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy // J. Immunol. 2003. — Vol. 170. — P. 3637−3644.
- Sharpe A.H., Wherry E.J., Ahmed R., Freeman G.J. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection // Nature Immunology. 2007. — Vol. 8. — P. 239−245.
- Sheridan J.P., Marsters S.A., Pitti R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors // Science. 1997. — Vol. 277.-P. 818−821.
- Shin S., Hur G.-H., Kim Y.-B., et al. Dehydroepiandrosterone and melatonin prevent Bacillus anthracis lethal toxin-induced TNF production in macrophages // Cell Biology and Toxicology. 2000. — Vol. 16, № 3. — P. 165−174.
- Shortman K., Liu Y.J. Mouse and human dendritic cell subtypes // Nat Rev Immunol. 2002. — Vol. 2. — P. 151−161.
- Shurin M.R., Panharipande P.P., Sikora S.S., et al. Characterization of dendritic cells obtained from mice treated with flt3 ligand and IL-12. In: Fourth Int. Symposium on Dendritic Cells in Fundamental and Clinical Immunology. -1996.-P. 5−10.
- Silberberg I., Baer R.L., Rosenthal S.A. The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs // J. Invest. Dermatol. 1976. — Vol. 66. — P. 210- 217.
- Smyth M.J., Thia K.Y., Street S.E., et al. Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma // J. Exp. Med. 2000. — Vol. 192.-P. 755−760.
- Stary G., Bangert Ch., Tauber M., Strohal R., Kopp T., Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells // JEM. 2007. — Vol. 204, № 6.-P. 1441−1451.
- Stary G., Klein I., Kohlhofer S., et al. Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients // Blood. -2009. Vol. 114. — P. 3854−3863.
- Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells // Annu. Rev. Immunol. 2003. — Vol. 21. — P. 685−711.
- Steinman R.M.The dendritic cell system and its role in immunogenicity // Annu. Rev. Immunol. 1991. — Vol. 9. — P. 271 -296.
- Szabolics P., Avigan D., Gezelter S., et al. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post colony-forming unit intermediate // Blood. 1996. — Vol. 87. — P. 4520−4530.
- Takaoka A., Taniguchi T. Cytosolic DNA recognition for triggering innate immune responses // Adv. Drug. Deliv. Rev. 2008. — Vol. 60. — P. 847−857.
- Tanaka H., Demeure C.E., Rubio M., et al. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Thl/Th2 effectors: role of stimulator/responder ratio // J. Exp. Med. 2000. — Vol. 192.-P. 405−412.
- Tartaglia L.A., Ayres T.M., Wong G.H.W., Goeddel D.V. A novel domain within the 55 kDa TNF receptor signals cell death // Cell. 1993. — Vol. 74. — P. 845−853.
- Terness P., Chuang J.J., Bauer T., et al. Regulation of human auto- and alloreactive T cells by indoleamine 2, 3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO? // Blood. 2005. — Vol. 105. — P. 2480−2486.
- Thornberry N.A., Lazebnik Y. Caspases: enemies within // Science. 1998. -Vol. 281.-P. 1312−1316.
- Thurner B., Roder C., Dieckmann D., et al. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application // J. Immunol. Methods. 1999. — Vol. 223. — P. 1−15.
- Treilleux I., Blay J.Y., Bendriss-Vermare N., et al. Dendritic cell infiltration and prognosis of early stage breast cancer // Clin. Cancer Res. 2004. — Vol. 10. -P. 7466−7474.
- Trinchieri G., Matsumoto-Kobayashi M., Clark S.C., et al. Response of resting human peripheral blood natural killer cells to interleukin 2 // J. Exp. Med. -1984. -Vol. 160.- P. l 147.
- Trinite B., Chauvin C., Peche H., et al. Immature CD4~CD103+ rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and nontumor cells and phagocytose their victims // J. Immunol. 2005. -Vol. 175.-P. 2408−2417.
- Van Kooyk Y., Geijtenbeek T.B. A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions // Immunol. Rev. 2002. — Vol. 186.-P. 47−56.
- Van Loo G., Saelens X., van Gurp M., et al. The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet // Cell Death Differ. 2002. — Vol. 9. — P. 1031−1042.
- Vandenabeele P., Declercq W., Vanhaesebroeck B., Grooten J., Fiers W. Both TNF receptors are required for TNF- mediated induction of apoptosis in PC60 cells // J. Immunol. 1995. — Vol. 154. — P. 2904−2913.
- Vanderheyde N., Aksoy E., Amraoui Z., et al. Tumoricidal activity of monocyte-derived dendritic cells: evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism // The Journal of Immunology. -2001. Vol. 167. — P. 3565−3569.
- Vanderheyde N., Vandenabeele P., Goldman M., Willems F. Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells // Immunology Letters. 2004. — Vol. 91. — P. 99−101.
- Vidalain P.O., Azocar O., Lamouille B., et al. Measles virus induces functional TRAIL production by human dendritic cells // J. Virol. 2000. — Vol. 74, № 1.-P. 556−559.
- Virag L., Szabo E., Gergely P., Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention // Toxicol. Lett. 2003. — Vol. 140−141.-P. 113−124.
- Wallach D., Varfolomeev E.E., Malinin N.L., et al. Tumor necrosis factor and Fas signaling mechanisms // Annu. Rev. Immunol. 1999. — Vol. 17. — P.331−367.
- Wesa A.K., Storkus W.J. Killer dendritic cells: mechanisms of action and therapeutic implications for cancer // Cell Death Differ. 2008. — Vol. 15. — P. 5157.
- West E., Morgan R., Scott K., et al. Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery // J. Immunother. 2009. — Vol. 32, № 1. — P. 66−78.
- Wojas K., Tabarkiewicz J., Jankiewicz M., Rolinski J. Dendritic cells in peripheral blood of patients with breast and lung cancer a pilot study // Folia Histochem. Cytobiol. — 2004. — Vol. 42. — P. 45−48.
- Wu C.Y., Kirman J.R., Rotte M.J. Distinct lineages of Thl cells have differential capacities for memory cell generation in vivo // Nat. Immunol. 2002. -Vol.3.-P. 852−858.
- Xu Y., He H., Li C., et al. Immunosuppressive effect of progesterone on dendritic cells in mice // J. Reprod Immunol. 2011. — Vol. 91, № 1−2. — P. 17−23.
- Yang R., Xu D., Zhang A., Gruber A. Immature dendritic cells kill ovarian carcinoma cells by a FAS/FASL pathway, enabling them to sensitize tumor-specific CTLs // Int. J. Cancer. 2001. — Vol. 94, № 3. — P. 407−413.
- Yellin M.J., Winikoff S., Fortune S.M., et al. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD 106 (VCAM-1) up-regulation and IL-6 production and proliferation // J. Leukocyte Biol. 1995. — Vol. 58. — P. 209−216.
- Yoneyama H., Matsuno K., Zhang Y. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules // Int. Immunol. 2004. — Vol. 16. — P. 915- 928.
- Zhang Z.J., Fu Q., Zhao Y., et al. Differential restoration of myeloid and plasmacytoid dendritic cells in HIV-1-infected children after treatment with highly active antiretroviral therapy // J. Immunol. 2006. — Vol. 176. — P. 5644−5651.
- Zhou L.J., Tedder T.F. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells // Proc. Natl. Acad. Sei. USA. 1996. -Vol. 93. — P. 2588−2592.
- Zuckerman S.H., Evans G.F. Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level // Cell. Immunol. 1992. — Vol.140. — P. 513.
- Zuniga E.I., McGavern D.B., Pruneda-Paz J.L., Teng Ch., Oldstone M.B. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection // Nature Immunology. 2004. — Vol. 5. — P. 1227 — 1234.