Изучение генетического разнообразия изолятов вируса гепатита С и факторов риска инфицирования у пациентов с острыми и хроническими гапатитами в Новосибирске
Диссертация
В значительной степени из-за того, что в России не проводилось молекулярно-эпидемиологических исследований вирусных гепатитов с использованием современных международно-признанных подходов, в 1999 году в лаборатории молекулярной биологии РНК-содержащих вирусов ГНЦ ВБ «Вектор» нами был начат цикл молекулярно-эпидемиологических исследований, направленных на изучение распространенности, факторов… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗОВАННЫХ СОКРАЩЕНИЙ
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Общие сведения о гепатите С и его возбудителе
- 1. 2. Структура вирусных частиц
- 1. 3. Строение генома ВГС
- 1. 3. 1. Нетранслируемые области
- 1. 3. 2. Структурные белки
- 1. 3. 3. Неструктурные белки
- 1. 3. 3. 4. Структура и функция белка NS5B
- 1. 4. Вариабельность генома ВГС
- 1. 4. 1. Уровни вариабельности
- 1. 4. 2. Уровень инфицированного индивида — квазивиды
- 1. 4. 3. Уровень эпидемической цепочки — изолдты
- 1. 4. 4. Уровень популяций — генотипы и субтипы
- 1. 5. Географическая распространённость генотипов ВГС
- 1. 5. 1. Генотипы ВГС в мире
- 1. 5. 2. Распределение генотипов ВГС в Российской Федерации
- 1. 6. Клиническое значение генотипов ВГС
- 1. 7. Методы генотипирования нзолятов ВГС
- 1. 7. 1. Коммерческие наборы для генотипирования
- 1. 7. 2. Некоммерческие методы генотипирования
- 1. 7. 3. Методы серотилирования
- 1. 8. Естественное течение вирусного гепапита С
- 1. 8. 1. Острый вирусный гепатит С
- 1. 8. 2. Хронический вирусный гепатит С
- 1. 8. 3. Цирроз и гепатоцеллюлярная карцинома
- 1. 8. 4. Внепечёночные проявления
- 1. 8. 5. Механизмы хронизации гепатита С
- 1. 9. Эпидемиология вирусного гепатита С
- 1. 9. 1. Распространенность
- 1. 9. 2. Пути передачи
- 1. 9. 3. Факторы риска
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