Молекулярно-эпидемиологический мониторинг гриппа в Азиатской части России
Диссертация
Период гнездования миллионы птенцов, и обширный «вокзал», в котором останавливается во время пролетов еще большее количество птиц, гнездящихся в тайге и тундре (Шестопалов, 2010). Территориальные связи западносибирских птиц, которые устанавливаются в процессе сезонных миграций, весьма обширны, поскольку здесь сходятся миграционные потоки птиц, зимующих в различных регионах мира — Европе, Африке… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗОВАННЫХ СОКРАЩЕНИЙ
- ОБЩАЯ ХАРАКТЕРИСТИКА РАБОТЫ
- АКТУАЛЬНОСТЬ РАБОТЫ
- ЦЕЛЬ И ЗАДАЧИ ИССЛЕДОВАНИЯ
- НАУЧНАЯ НОВИЗНА
- ПОЛОЖЕНИЯ, ВЫНОСИМЫЕ НА ЗАЩИТУ
- I. ОБЗОР ДАННЫХ ЛИТЕРАТУРЫ
- 1. 1. СТРОЕНИЕ ВИРУСА ГРИППА
- 1. 1. 1. Строение вириона
- 1. 1. 2. Геном и белки вируса гриппа
- 1. 1. 3. Репликативный цикл вируса гриппа
- 1. 2. ЭВОЛЮЦИЯ АНТИГЕННЫХ СВОЙСТВ ВИРУСА ГРИППА
- 1. 2. 1. Структура гемагглютинина и нейраминидазы
- 1. 2. 2. Антигенный дрейф
- 1. 2. 3. Антигенный шифт (сдвиг)
- 1. 3. ЭПИДЕМИОЛОГИЯ ГРИППА
- 1. 3. 1. Первые исторически зафиксированные эпидемии и пандемии гриппа
- 1. 3. 2. Пандемии гриппа в XX веке
- 1. 3. 2. 1. Пандемия гриппа А (НINI) в 1918- 1920-х гг. («испанка»)
- 1. 3. 2. 2. Пандемия «азиатского гриппа» A (H2N2) в 1957 — 1959 гг
- 1. 3. 2. 3. Пандемия «гонконгского гриппа» A (H3N2) (1968 — 1970 гг.)
- 1. 3. 2. 4. Пандемия Русского гриппа A (H1N1) (1977- 1978 гг.)
- 1. 3. 2. 5. Эпидемия гриппа A (HINI) в 1946- 1947 гг
- 1. 3. 3. Пандемия гриппа А (НINI) в XXI веке
- 1. 3. 4. Заболевания человека, вызванные вирусами гриппа свиней
- 1. 3. 5. Заболевания человека, вызванные вирусами гриппа птиц
- 1. 3. 6. Эпидемиология гриппа В
- 1. 3. 7. Эпидемиология сезонного гриппа
- 1. 4. ПАТОГЕНЕЗ
- 1. 4. 1. Патогенез при инфицировании вирусом гриппа человека
- 1. 4. 2. Особенности патогенеза при заражении человека вирусами гриппа птиц подтипа A (H5N1)
- 1. 4. 3. Патогенез при заражении человека вирусами гриппа птиц H7N7, H7N3, H7N2, H9N
- 1. 4. 4. роль вирусных белков в адаптации к хозяину и патогенезе
- 1. 4. 4. 1. Белки полимеразного комплекса
- 1. 4. 4. 2. Гемагглютинин
- 1. 4. 4. 3. Неструктурный белок NS
- 1. 4. 4. 4. Роль других белков вируса гриппа в патогенезе
- 1. 1. СТРОЕНИЕ ВИРУСА ГРИППА
- 1. 5. ИММУНИТЕТ ПРИ ГРИППЕ
- 1. 5. 1. неспецифический иммунитет
- 1. 5. 1. 1. Рецепторы распознавания патоген-ассоциированных молекулярных структур в респираторном тракте
- 1. 5. 1. 1. 1. Толл-подобные рецепторы (toll-like receptors — TLR)
- 1. 5. 1. 1. 2. НОД-подобные рецепторы (nucleotide oligomerization domain-like receptors — NLR)
- 1. 5. 1. 1. 3. RIG-I-подобные рецепторы (retinoic acic induced gene I-like receptors — RLR)
- 1. 5. 1. 1. 4. Цитокины
- 1. 5. 1. 2. Связь между врожденным и адаптивным иммунными ответами
- 1. 5. 2. Адаптивный иммунный ответ на вирус гриппа А
- 1. 5. 2. 1. Гуморальный ответ
- 1. 5. 2. 2. Цитотоксический Т-клеточный ответ
- 1. 5. 3. Влияние популяционного иммунитета на смену серотипов вируса гриппа
- 1. 5. 1. неспецифический иммунитет
- 1. 6. ПОЯВЛЕНИЕ ПАНДЕМИЧЕСКИХ ВИРУСОВ ГРИППА А
- 1. 6. 1. Дискуссия о появлении шифтовых вариантов вируса гриппа
- 1. 6. 2. Современные представления о возникновении пандемических вирусов гриппа
- 1. 6. 2. 1. Появление «испанки» 1918 г
- 1. 6. 2. 2. Появление азиатского (1957 г.) и гонконгского (1968 г.) гриппа
- 1. 6. 2. 3. Появление пандемического вируса A (HlNl)pdm
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